| Pair Name | Liriodenine, Valproic acid | ||
| Phytochemical Name | Liriodenine (PubChem CID: 10144 ) | ||
| Anticancer drug Name | Valproic acid (PubChem CID: 3121 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Liriodenine, Valproic acid | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | GCLC | hsa2729 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| Result | Liriodenine enhances the apoptosis effect of valproic acid in human colon cancer cells through oxidative stress upregulation and Akt inhibition | |||
| No. | Title | Href |
|---|---|---|
| 1 | Liriodenine enhances the apoptosis effect of valproic acid in human colon cancer cells through oxidative stress upregulation and Akt inhibition | Click |
